4-丁基-3,5-二甲基-1H-吡咯-2-羧酸乙酯合成路线 （共 15 条）
反应条件
sodium hydroxide; benzoyl chloride 1.) ethylene glycol, reflux 45 min, 2.) toluene, -5-0 deg C, 1 h; Yield givenMultistep reaction;
参考文献
Lash, Timothy D.; Mani, Ukti N.; Drinan, Martin A.; Zhen, Chun; Hall, Troii; Jones, Marjorie A.
Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 464 - 477
反应条件
potassium hydroxide in ethylene glycol Decarboxylation; ester cleavage; 1 h; Heating;
参考文献
Berezin; Semeikin; Antina; Pashanova; Lehedeva; Bukushina
Russian Journal of General Chemistry, 1999 , vol. 69, # 12 p. 1949 - 1955
反应条件
1: 78 percent / acetic anhydride / acetic acid / 3 h / 20 °C 2: 88 percent / conc. HCl / methanol / 3 h / Heating 3: sodium hydroxide / ethane-1,2-diol / 1 h / 180 °C View Scheme
参考文献
Mamardashvili, N. Zh.; Semeikin, A. S.; Golubchikov, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 6.2 p. 1007 - 1015
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 6 p. 1213 - 1223
反应条件
sodium
T=80°C; P=15 Torr; 4 h;
参考文献
Lecas-Nawrocka, Alexandra; Levisalles, Jacques; Mariacher, Claire; Renko, Zafiarisoa; Rose, Eric
Canadian Journal of Chemistry, 1984 , vol. 62, p. 2054 - 2058
反应条件
in benzyl alcohol
T=20 - 230°C; 1.58333 h;
参考文献
Lash, Timothy D.; Smith, Breland E.; Melquist, Michael J.; Godfrey, Bradley A.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5335 - 5345
