5-甲基-3-氨基-2-氯吡啶合成路线 （共 4 条）
反应条件
1: With ethanol; tin(ll) chloride T=50 - 55°C; 2 h; 2: With sodium hydroxide in dichloromethane; water
参考文献
WO2006/42102 A2, ;
Page/Page column 49-50 ;
WO 2006/042102 A2
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 1 h; Inert atmosphere; 2: With copper(l) chloride in water T=0°C; 1 h; Inert atmosphere;
参考文献
Friedman, Adam A.; Panteleev, Jane; Tsoung, Jennifer; Huynh, Vaizanne; Lautens, Mark
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9755 - 9758
反应条件
1: pyridine / dioxane; cyclohexane / Ambient temperature 2: xylene / Heating 3: NaH / various solvent(s) / Heating 4: 1.) NaH / 1.) DMSO, 2.) DMSO View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
sodium hydroxide 0.25 h;
参考文献
Setliff, Frank L.; Rankin, Steve H.
Journal of Chemical & Engineering Data, 1988 , vol. 33, # 2 p. 223
