2-氯-3-氟-5-甲基吡啶合成路线 （共 4 条）
反应条件
hydrogenchloride in acetonitrile T=180°C; 0.333333 h;
参考文献
The Dow Chemical Company
Patent: US4562009 A1, 1985 ;
反应条件
pyridine; potassium permanganate; water T=100°C; 4 h;
参考文献
ASTRAZENECA AB; BYLUND, Johan; EK, Maria, E; HOLENZ, Joerg; KERS, Annika; OeHBERG, Liselotte
Patent: WO2010/132016 A1, 2010 ;
Location in patent: Page/Page column 91 ;
WO 2010/132016 A1
反应条件
1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / Reflux 2: silver nitrate / ethanol; water / 1 h / 100 °C View Scheme
参考文献
GLAXO GROUP LIMITED; WAN, Zehong; ZHANG, XIaomin; WANG, Jian; PENG, Cheng; JIN, Yun; HU, Yimin
Patent: WO2012/75917 A1, 2012 ;
WO 2012/075917 A1
反应条件
N-chloro-succinimide; 2,2'-azo-bisisobutyronitrile in chlorobenzene
Reflux;
参考文献
Bayer CropScience AG
Patent: US2010/48646 A1, 2010 ;
Location in patent: Page/Page column 26 ;
