2,3,4,9-四氢-1H-咔唑-1-酮合成路线 （共 50 条）
反应条件
PPA in toluene 5 h; Heating;
参考文献
Maingot, Lucie; Thuaud, Frederic; Sissouma, Drissa; Collet, Sylvain; Guingant, Andre; Evain, Michel
Synlett, 2008 , # 2 p. 263 - 267
反应条件
1: ethyl 2-oxo-cyclohexanecarboxylate With potassium hydroxide in water T=30°C; 4 h; 2: aniline With hydrogenchloride; sodium nitrite in water T=0°C; 1 h; Further stages;
参考文献
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN; INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY; HONARNEJAD, Kamran; DASCHNER, Alexander; HERMS, Jochen; BRACHER, Franz; KUZNICKI, Jacek; GEHRING, André Philipe
Patent: WO2013/139929 A1, 2013 ;
Location in patent: Page/Page column 44; 45 ;
反应条件
acetic anhydride; bis-[(trifluoroacetoxy)iodo]benzene T=20°C; 0.166667 h; Reagent/catalystSolventConcentrationTemperatureTime;
参考文献
Shi, Hao; Guo, Tianjian; Zhang-Negrerie, Daisy; Du, Yunfei; Zhao, Kang
Tetrahedron, 2014 , vol. 70, # 17 p. 2753 - 2760
反应条件
sulfuric acid in water; acetonitrile 4 h; Reflux;
参考文献
Wu, Zhijie; Li, Ying; Cai, Yu; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 17 p. 4903 - 4906
反应条件
periodic acid in tetrahydrofuran; water T=0°C;
参考文献
Di Fabio, Romano; Giovannini, Riccardo; Bertani, Barbara; Borriello, Manuela; Bozzoli, Andrea; Donati, Daniele; Falchi, Alessandro; Ghirlanda, Damiano; Leslie, Colin P.; Pecunioso, Angelo; Rumboldt, Giovanna; Spada, Simone
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1749 - 1752
反应条件
dirhodium tetraacetate in dichloromethane T=20°C; Cyclization;
参考文献
Salim, Mohamed; Capretta, Alfredo
Tetrahedron, 2000 , vol. 56, # 41 p. 8063 - 8069
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran; water T=0 - 20°C; 5.5 h;
参考文献
Journal of Chemical Crystallography, , vol. 25, # 5 p. 249 - 258
反应条件
1: ethyl 2-oxo-cyclohexanecarboxylate With potassium hydroxide in water T=0 - 30°C; Japp-Klingemann reaction; 4 h; 2: benzene diazonium chloride in water T=0°C; Japp-Klingemann reaction; 3: With formic acid in water T=80°C; Fischer cyclization; 12 h;
参考文献
Gehring, Andrep.; Bracher, Franz
Synthesis (Germany), 2012 , vol. 44, # 15 p. 2441 - 2447
反应条件
1: With sodium hydroxide; water T=20°C; 0.25 h; 2: With water; acetic acid Fischer indole synthesis; 5 h; Reflux;
参考文献
Sheng, Rong; Shen, Li; Chen, You-Qin; Hu, Yong-Zhou
Synthetic Communications, 2009 , vol. 39, # 6 p. 1120 - 1127
反应条件
1: SOCl2; DMF / tetrahydrofuran / 2 h / 0 °C 2: 95 percent / Rh2(OAc)4 / CH2Cl2 / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 41 p. 8063 - 8069
