2-(二甲基氨基)-4,6-二甲基-5-嘧啶醇合成路线 （共 6 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 5 h;
参考文献
ARIZONA BOARD OF REGENTS; HECHT, Sidney; ARMSTRONG, Jeffrey; KHDOUR, Omar; LU, Jun; ARCE, Pablo
Patent: WO2011/103536 A1, 2011 ;
Location in patent: Page/Page column 41-42 ;
WO 2011/103536 A1
反应条件
1: With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in 1,4-dioxane; water T=100°C; 4 h; Inert atmosphere; 2: With hydrogenchloride in water pH=~ 7;
参考文献
ARIZONA BOARD OF REGENTS; HECHT, Sidney; ARMSTRONG, Jeffrey; KHDOUR, Omar; LU, Jun; ARCE, Pablo
Patent: WO2011/103536 A1, 2011 ;
Location in patent: Page/Page column 48-49 ;
WO 2011/103536 A1
反应条件
1: in water T=80°C; 1 h; Sealed tubeMicrowave irradiation; 2: With sodium hydroxide in water T=80°C; 1 h; Microwave irradiation;
参考文献
Renard, Brice-Loic; Boucherle, Benjamin; Maurin, Bruno; Molina, Marie-Carmen; Norez, Caroline; Becq, Frederic; Decout, Jean-Luc
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1935 - 1941
反应条件
sodium acetate in N,N-dimethyl-formamide T=100°C; 4 h;
参考文献
Valgimigli, Luca; Brigati, Giovanni; Pedulli, Gian Franco; DiLabio, Gino A.; Mastragostino, Marina; Arbizzani, Catia; Pratt, Derek A.
Chemistry - A European Journal, 2003 , vol. 9, # 20 p. 4997 - 5010
反应条件
sodium cyanoborohydride in methanol; water 2 h;
参考文献
Roschek Jr., Bill; Tallman, Keri A.; Rector, Christopher L.; Gillmore, Jason G.; Pratt, Derek A.; Punta, Carlo; Porter, Ned A.
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3527 - 3532
反应条件
1: 80 percent / dimethylsulfoxide / 3 h / 20 °C 2: 30 percent / NaOAc / dimethylformamide / 4 h / 100 °C View Scheme
参考文献
Valgimigli, Luca; Brigati, Giovanni; Pedulli, Gian Franco; DiLabio, Gino A.; Mastragostino, Marina; Arbizzani, Catia; Pratt, Derek A.
Chemistry - A European Journal, 2003 , vol. 9, # 20 p. 4997 - 5010
