4,4'-二甲基苯偶酰合成路线 （共 111 条）
反应条件
Multistep reaction.;
参考文献
Traversone, Antonio; Brill, Wolfgang K.-D.
Tetrahedron Letters, 2007 , vol. 48, # 20 p. 3535 - 3538
反应条件
1: in tetrahydrofuran; diethyl ether
T=-78°C; dianionic oxy Cope rearrangement; 1.5 h;
2: With ammonium chloride in diethyl ether
T=-78°C; 1 h;
参考文献
Clausen, Christian; Wartchow, Rudolf; Butenschoen, Holger
European Journal of Organic Chemistry, 2001 , # 1 p. 93 - 113
反应条件
[bbim](+)Br(-) in dimethyl sulfoxide
T=70°C; 0.666667 h;
参考文献
Tamboli, Riyaj S.; Giridhar, Rajani; Mande, Hemant M.; Shah, Shailesh R.; Yadav, Mange Ram
Synthetic Communications, 2014 , vol. 44, # 15 p. 2192 - 2204
参考文献
Eli Lilly and Company
Patent: US4513135 A1, 1985 ;
US 4513135 A
反应条件
sodium hydrogencarbonate in methanol
12 h; Ambient temperature;
参考文献
Sasaki, Tadashi; Minamoto, Katsumaro; Harada, Katsuhiko
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4587 - 4593
反应条件
in ethanol; water
10 h; Heating;
参考文献
Heilman; Scozzie; Wayner; Gullo; Ariyan
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 3 p. 282 - 287
反应条件
aluminium trichloride
T=40°C; 24 h; Further byproducts given;
参考文献
Sakaino; Sugawara; Terao; Fujiwara; Mori; Maeda
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 1996 , vol. 276-277, # pt 1-2 p. 271 - 275
反应条件
titanium tetrachloride; zinc in tetrahydrofuran
T=20°C; Inert atmosphereReflux;
参考文献
Lin, Wei; Hu, Ming-Hua; Feng, Xian; Fu, Lei; Cao, Cheng-Pao; Huang, Zhi-Bin; Shi, Da-Qing
Tetrahedron Letters, 2014 , vol. 55, # 14 p. 2238 - 2242
反应条件
acetic acid in ethanol; water
29 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2004/111034 A1, 2004 ;
Location in patent: Page 65 ;
WO 2004/111034 A1
反应条件
ammonium acetate; [HBIM](1+)*BF4(1-)
T=100°C; 1.83333 h;
参考文献
Siddiqui, Shapi A.; Narkhede, Umesh C.; Palimkar, Sanjay S.; Daniel, Thomas; Lahoti, Rajgopal J.; Srinivasan, Kumar V.
Tetrahedron, 2005 , vol. 61, # 14 p. 3539 - 3546
