3-氯-6-甲基苯并[b]噻吩-2-羧酸合成路线 （共 3 条）
反应条件
hydrogenchloride; NaOH; ammonium formate; palladium monocarbide in methanol; water; ethyl acetate
参考文献
MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A.
Patent: US2012/65370 A1, 2012 ;
反应条件
1: With hydrogen; sodium hydroxide; 5 Pd(II)/C(eggshell) in tetrahydrofuran; methanol T=20°C; Inert atmosphere; 2: With hydrogenchloride in water; ethyl acetate Product distribution / selectivity;
参考文献
MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A.; BONACCORSI, Fabrizio; FEDI, Valentina; GIANNOTTI, Danilo
Patent: WO2010/133306 A1, 2010 ;
Location in patent: Page/Page column 9; 24; 25 ;
反应条件
hydrogenchloride; NaOH in tetrahydrofuran; methanol; ethyl acetate
参考文献
MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A.
Patent: US2012/65370 A1, 2012 ;
