6-氟-1,2-二氢-2-氧代螺[4H-3,1-苯并恶嗪-4,4'-哌啶]-1'-羧酸叔丁酯合成路线 (共 2 条)
反应条件
1: (4-fluoro-phenyl)-carbamic acid tert-butyl ester With tert.-butyl lithium in tetrahydrofuran T=-78 - -25°C; 2.5 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran T=-78°C; 4 h; 3: With potassium tert-butylate in tetrahydrofuran T=-78 - 20°C; 18 h;
参考文献
US2005/176703 A1, ;
Page/Page column 44 ;
US 20050176703 A1
反应条件
1: (4-fluoro-phenyl)-carbamic acid tert-butyl ester With n-butyllithium in tetrahydrofuran; hexane T=-70 - -20°C; 3.33333 h; 2: 2-(3,4-dichloro-phenyl)-4-oxo-butyric acid methyl ester With potassium tert-butylate in tetrahydrofuran; hexane T=-60 - 20°C; 14 h;
参考文献
WO2008/81012 A1, ;
Page/Page column 42 ;
WO 2008/081012 A1