1-(4-溴苯基)环丙甲酸合成路线 （共 13 条）
反应条件
1: With potassium hydroxide in water; ethylene glycol T=135 - 140°C; 4 h; 2: With hydrogenchloride in water
参考文献
US6359135 B1, ;
Page column 113 ;
反应条件
1: With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide in water T=50°C; 3 h; 2: With ethanol T=100°C; 72 h;
参考文献
EP2700643 A1, ;
Paragraph 0200 ;
反应条件
N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide in water T=70 - 150°C; 22 h;
参考文献
WO2013/38429 A2, ;
Page/Page column 75-76 ;
反应条件
bromine; sodium acetate; acetic acid T=5 - 50°C; 48 h;
参考文献
US2008/81802 A1, ;
Page/Page column 8 ;
反应条件
potassium hydroxide in water T=135 - 140°C; 4 h;
参考文献
US6369261 B1, ;
Page column 111 ;
反应条件
1.1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 2.17 h / 20 °C 2.1: potassium hydroxide / ethylene glycol / 4 h / 180 °C 2.2: Acidic conditions View Scheme
参考文献
US2011/82164 A1, ;
WO2012/78593 A2, ;
WO 2012/078593 A2
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=0 - 20°C; 4 h; Inert atmosphere;
参考文献
PANACEA BIOTEC LTD.; JAIN, Rajesh; TREHAN, Sanjay; DAS, Jagattaran; NANDA, Gurmeet, Kaur; THUNGATHURTHI, Sastry, V., R., S.; SINGH, Nishan; SHARMA, Sudhir, Kumar
Patent: WO2013/38429 A2, 2013 ;
Location in patent: Page/Page column 76 ;
反应条件
diphenyl phosphoryl azide; triethylamine 17 h; Heating / refluxNeat (no solvent);
参考文献
Allergan Sales, Inc.
Patent: US6369225 B1, 2002 ;
Location in patent: Page column 42, 112 ;
反应条件
1: 1-(4-bromophenyl)-cyclopropanecarboxylic acid; tert-butyl alcohol With diphenyl phosphoryl azide; triethylamine 15 h; Heating / reflux; 2: di-tert-butyl dicarbonate in tert-butyl alcohol 15 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/63239 A1, 2005 ;
Location in patent: Page/Page column 129 ;
WO 2005/063239 A1
反应条件
1: sulfuric acid / 1 h / 75 °C 2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere View Scheme
参考文献
AMIRA PHARMACEUTICALS, INC.
Patent: US2012/258987 A1, 2012 ;
US 20120258987 A1
