1-[(2R,3R,4S,5R)-3,4-二羟基-5-(羟基甲基)四氢呋喃-2-基]-4-氧代吡嗪-4-鎓-2-酮合成路线 (共 6 条)
反应条件
1: SnCl4 / CH2Cl2 / 1.5 h / Ambient temperature 2: 85 percent / NH3 in MeOH / 7 h / 0 °C 3: 83 percent / pyridine / Ambient temperature 4: 28percent NaOMe in MeOH / Ambient temperature View Scheme
参考文献
Mano; Seo; Hattori; Kaneko; Imai
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2734 - 2747
反应条件
1: SnCl4 / 1,2-dichloro-ethane; acetonitrile / 24 h / Heating 2: 28percent NaOMe in MeOH / Ambient temperature View Scheme
参考文献
Mano; Seo; Hattori; Kaneko; Imai
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2734 - 2747
反应条件
sodium methylate Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Mano; Seo; Hattori; Kaneko; Imai
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2734 - 2747
反应条件
1: 85 percent / NH3 in MeOH / 7 h / 0 °C 2: 83 percent / pyridine / Ambient temperature 3: 28percent NaOMe in MeOH / Ambient temperature View Scheme
参考文献
Mano; Seo; Hattori; Kaneko; Imai
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2734 - 2747
反应条件
1: 83 percent / pyridine / Ambient temperature 2: 28percent NaOMe in MeOH / Ambient temperature View Scheme
参考文献
Mano; Seo; Hattori; Kaneko; Imai
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2734 - 2747
反应条件
1: 83 percent / pyridine / Ambient temperature 2: 28percent NaOMe in MeOH / Ambient temperature View Scheme
参考文献
Mano; Seo; Hattori; Kaneko; Imai
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2734 - 2747