4-氯-7-三氟甲基喹啉合成路线 （共 23 条）
反应条件
3-chloro-benzenecarboperoxoic acid in chloroform
T=20°C; 3.5 h;
参考文献
TOYAMA CHEMICAL CO., LTD.; TAISHO PHARMACEUTICAL CO., LTD
Patent: EP1900732 A1, 2008 ;
Location in patent: Page/Page column 119 ;
EP 1900732 A1
反应条件
1.1: 90 percent / hydrogen; triethylamine / palladium on carbon / methanol
2.1: various solvent(s) / 2 h / 150 °C / cooling
2.2: 77 percent / Heating
3.1: 82 percent / REDAL / tetrahydrofuran; toluene / 4 h / -20 °C
View Scheme
参考文献
Gueller, Rolf; Binggeli, Alfred; Breu, Volker; Bur, Daniel; Fischli, Walter; Hirth, Georges; Jenny, Christian; Kansy, Manfred; Montavon, Francois; Mueller, Marcel; Oefner, Christian; Stadler, Heinz; Vieira, Eric; Wilhelm, Maurice; Wostl, Wolfgang; Maerki, Hans Peter
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 10 p. 1403 - 1408
反应条件
1.1: 90 percent / hydrogen; triethylamine / palladium on carbon / methanol
2.1: various solvent(s) / 2 h / 150 °C / cooling
2.2: 77 percent / Heating
View Scheme
参考文献
Cody, Wayne L.; Holsworth, Daniel D.; Powell, Noel A.; Jalaie, Mehran; Zhang, Erli; Wang, Wei; Samas, Brian; Bryant, John; Ostroski, Robert; Ryan, Michael J.; Edmunds, Jeremy J.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 1 p. 59 - 68
