Drummond, J.; Johnson, G.; Nickell, D. G.; Ortwine, D. F.; Bruns, R. F.; Welbaum, B.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2116 - 2128
1: (1R)-(-)-2-azabicyclo[2.2.1]hept-5-en-3-one With methanesulfonic acid in tetrahydrofuran; water
T=34 - 44°C; 2.75 h; Heating / reflux;
2: With lithium aluminium tetrahydride in tetrahydrofuran
18.5 h; Heating / reflux;
3: carbonic acid di-tert-butyl ester With NAF
more than 3 stages;