1: 1-Amino-4-chloro-2-butyne hydrochloride With sodium hydroxide in 1,4-dioxane; water
0.5 h;
2: carbonic acid di-tert-butyl ester in trans-1,3-dioxane; water
T=20 - 25°C; 8 h;
参考文献
G. D. Searle and Co.
Patent: US6344483 B1, 2002 ;
Location in patent: Page column 19 ;
diisopropylamine in 1,4-dioxane; water
T=20°C; 60 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; PEREZ, Heidi L.; STANG, Erik M.; KIM, Kyoung S.
Patent: WO2013/192286 A1, 2013 ;
Location in patent: Paragraph 00216 ;