(S)-2-哌啶酮-6-羧酸合成路线 （共 15 条）
反应条件
1: 81.5 percent / 1 N aq. HCl / 3 h / Heating 2: 68 percent / 20percent aq. AcOH / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1654 - 1658
反应条件
thionyl chloride T=20°C; Inert atmosphere;
参考文献
McKinnell, Robert Murray; Long, Daniel D.
Patent: US2013/287731 A1, 2013 ;
Location in patent: Paragraph 0321; 0322 ;
反应条件
borane-THF in tetrahydrofuran T=0°C; 1 h;
参考文献
Huang, Sung-Ben; Nelson, Jeffrey S.; Weller, Dwight D.
Synthetic Communications, 1989 , vol. 19, # 20 p. 3485 - 3496
反应条件
1: 68 percent / dicyclohexylcarbodiimide (DCCI), hydroxybenzotriazole (HOBt), NEt3 / CH2Cl2 / 1 h / 25 °C
2: mercaptoethanol / dimethylformamide / 0.5 h / 25 °C
View Scheme
参考文献
Nutt; Holly; Homnick; Hirschmann; Veber; Arison
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698
反应条件
1: 92 percent / dicyclohexylcarbodiimide / ethyl acetate / 3 h / 0 - 5 °C
2: 86 percent / NEt3 / dimethylformamide / 2 h / 0 - 5 °C
View Scheme
参考文献
Szirtes, Tamas; Kisfaludy, Lajos; Palosi, Eva; Szporny, Laszlo
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1654 - 1658
