4-氯-2-(氯甲基)喹唑啉合成路线 （共 4 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene T=65°C; 2: With sodium hydrogencarbonate in water; toluene
参考文献
MYRIAD PHARMACEUTICALS, INC.; ANDERSON, Mark, B.; KIM, In, Chul
Patent: WO2010/6115 A1, 2010 ;
Location in patent: Page/Page column 5; 6 ;
反应条件
hydrogenchloride in 1,4-dioxane 12 h; Ambient temperature;
参考文献
Shishoo, C. J.; Devani, M. B.; Bhadti, V. S.; Anathan, S.; Ullas, G. V.
Tetrahedron Letters, 1983 , vol. 24, # 42 p. 4611 - 4612
反应条件
1: L-alloisoleucine amide; hydrochloride; 4-chloro-2-chloromethylquinazoline With potassium carbonate in acetonitrile
T=80°C; 25 h;
2: ethanol With potassium carbonate in acetonitrile
T=80°C; 46 h;
参考文献
Schering Corporation
Patent: US2007/15774 A1, 2007 ;
Location in patent: Page/Page column 212 ;
反应条件
hydrazine hydrate in tetrahydrofuran; dichloromethane
参考文献
Hoffmann-La Roche Inc.
Patent: US5387585 A1, 1995 ;
US 5387585 A
