N-[(E)-3-(2-氨基-3H-咪唑-4-基)丙-2-烯基]-4,5-二溴-1H-吡咯-2-甲酰胺合成路线 （共 10 条）
反应条件
trifluoroacetic acid in dichloromethane T=50°C; 2 h;
参考文献
Schroif-Gregoire, Cosima; Travert, Nathalie; Zaparucha, Anne; Al-Mourabit, Ali
Organic Letters, 2006 , vol. 8, # 14 p. 2961 - 2964
反应条件
hydrogenchloride in ethanol T=20°C; 1 h; Inert atmosphere;
参考文献
Ando, Naoki; Terashima, Shiro
Tetrahedron, 2010 , vol. 66, # 32 p. 6224 - 6237
反应条件
hydrazine hydrate T=20°C; 0.5 h;
参考文献
Rasapalli, Sivappa; Kumbam, Venkatreddy; Dhawane, Abasaheb N.; Golen, James A.; Lovely, Carl J.; Rheingold, Arnold L.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 25 p. 4133 - 4137
反应条件
1: 20 percent / NaBH4 / tetrahydrofuran / 1.75 h / -78 °C 2: 42 percent / bromine / dimethylformamide; acetonitrile / 1 h / 20 °C 3: 47 percent / triethylamine; hydroxylamine hydrochloride / ethanol / 1 h / Heating 4: 71 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 50 °C View Scheme
参考文献
Schroif-Gregoire, Cosima; Travert, Nathalie; Zaparucha, Anne; Al-Mourabit, Ali
Organic Letters, 2006 , vol. 8, # 14 p. 2961 - 2964
反应条件
1: 42 percent / bromine / dimethylformamide; acetonitrile / 1 h / 20 °C 2: 47 percent / triethylamine; hydroxylamine hydrochloride / ethanol / 1 h / Heating 3: 71 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 50 °C View Scheme
参考文献
Schroif-Gregoire, Cosima; Travert, Nathalie; Zaparucha, Anne; Al-Mourabit, Ali
Organic Letters, 2006 , vol. 8, # 14 p. 2961 - 2964
反应条件
1: sodium tetrahydroborate / water; tetrahydrofuran / 0.5 h / 0 - 20 °C 2: acetic acid / 8 h / 70 °C 3: hydrazine hydrate / 0.5 h / 20 °C View Scheme
参考文献
Rasapalli, Sivappa; Kumbam, Venkatreddy; Dhawane, Abasaheb N.; Golen, James A.; Lovely, Carl J.; Rheingold, Arnold L.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 25 p. 4133 - 4137
反应条件
1: 92 percent / H2NNH2 / ethanol / 2 h / 50 °C 2: 79 percent / Na2CO3 / dimethylformamide / 20 °C 3: 92 percent / aq. HCl / ethanol / 1 h / 20 °C View Scheme
参考文献
Ando, Naoki; Terashima, Shiro
Synlett, 2006 , # 17 p. 2836 - 2840
反应条件
1: 79 percent / Na2CO3 / dimethylformamide / 20 °C 2: 92 percent / aq. HCl / ethanol / 1 h / 20 °C View Scheme
参考文献
Ando, Naoki; Terashima, Shiro
Synlett, 2006 , # 17 p. 2836 - 2840
反应条件
1: 79 percent / Na2CO3 / dimethylformamide / 20 °C 2: 92 percent / aq. HCl / ethanol / 1 h / 20 °C View Scheme
参考文献
Ando, Naoki; Terashima, Shiro
Synlett, 2006 , # 17 p. 2836 - 2840
反应条件
1: acetic acid / 8 h / 70 °C 2: hydrazine hydrate / 0.5 h / 20 °C View Scheme
参考文献
Rasapalli, Sivappa; Kumbam, Venkatreddy; Dhawane, Abasaheb N.; Golen, James A.; Lovely, Carl J.; Rheingold, Arnold L.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 25 p. 4133 - 4137
