4-氯-5,7-二氢-6H-吡咯并[2,3-D]嘧啶-6-酮合成路线 （共 17 条）
反应条件
1: With pyridinium hydrobromide perbromide; acetic acid in tert-butyl alcohol 2: With acetic acid; zinc
参考文献
Sun; Cui, Jean; Liang, Congxin; Zhou, Yong; Nematalla, Asaad; Wang, Xueyan; Chen, Hui; Tang, Cho; Wei, James
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 16 p. 2153 - 2157
反应条件
ammonia in methanol T=60°C; 6 h;
参考文献
Synthesis (Germany), , vol. 44, # 15 p. 2396 - 2400
反应条件
ammonia in butan-1-ol T=95°C; 12 h;
参考文献
Synthesis (Germany), , vol. 44, # 15 p. 2396 - 2400
反应条件
ammonia in isopropyl alcohol T=90°C; 16 h;
参考文献
Synthesis (Germany), , vol. 44, # 15 p. 2396 - 2400
反应条件
1: ammonia / water / 6 h / 60 °C 2: carbon / ethyl acetate / 1 h / Reflux View Scheme
参考文献
Synthesis (Germany), , vol. 44, # 15 p. 2396 - 2400
反应条件
1: sodium methylate / methanol / 0 - 25 °C / Inert atmosphere 2: trichlorophosphate 3: ammonia / methanol / 6 h / 60 °C 4: carbon / ethyl acetate / 1 h / Reflux View Scheme
参考文献
Synthesis (Germany), , vol. 44, # 15 p. 2396 - 2400
反应条件
ammonia in isopropyl alcohol T=105°C; 24 h;
参考文献
Synthesis (Germany), , vol. 44, # 15 p. 2396 - 2400
反应条件
ammonia in isopropyl alcohol T=95°C; 24 h;
参考文献
Synthesis (Germany), , vol. 44, # 15 p. 2396 - 2400
反应条件
1: sodium methylate / methanol / 0 - 25 °C / Inert atmosphere 2: trichlorophosphate 3: ammonia / methanol / 6 h / 60 °C View Scheme
参考文献
Synthesis (Germany), , vol. 44, # 15 p. 2396 - 2400
反应条件
1.1: 92 percent / POCl3 2.1: pyridinium bromide perbromide; AcOH / 2-methyl-propan-2-ol 2.2: 36 percent / Zn; AcOH View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 16 p. 2153 - 2157
