4-羟基-4-(3-甲硫基苯基)-哌啶-1-羧酸叔-丁酯合成路线 （共 2 条）
反应条件
1: 1-bromo-3-methylsulphanyl-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; 0.583333 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran; hexane T=20°C; 1 h; 3: With ammonium chloride in tetrahydrofuran; hexane
参考文献
A. CARLSSON RESEARCH AB
Patent: US2006/135531 A1, 2006 ;
Location in patent: Page/Page column 13 ;
US 20060135531 A1
反应条件
1: 1-bromo-3-methylsulphanyl-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78 - -20°C; 0.533333 h; Inert atmosphere; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere; 3: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
Pettersson, Fredrik; Ponten, Henrik; Waters, Nicholas; Waters, Susanna; Sonesson, Clas
Journal of Medicinal Chemistry, 2010 , vol. 53, # 6 p. 2510 - 2520
