1: 1-methyl-pyrrole With n-butyllithium in hexane 0.333333 h; Heating; 2: thien-2-yl bromide With zinc(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran 6 h; Heating;

Pd0(tris(tert-butyl)phosphine)2; tetrabutyl-ammonium chloride; caesium carbonate in N,N-dimethyl-formamide T=170°C; 0.133333 h; Microwave irradiation;

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride Negishi coupling reaction; Inert atmosphere;

(i) BuLi, Et2O, (ii) CuBr, (iii) /BRN= 1634720/, Py; Multistep reaction;

(i) nBuLi, 1,2-bis-dimethylamino-ethane, Et2O, (ii) CuBr, (iii) /BRN= 104666/, Py; Multistep reaction;