1: With diacetone-2-ketogulonic acid in methanol; water RefluxResolution of racemate; 2: With sodium hydroxide in water T=25 - 30°C; 1 h; Product distribution / selectivity;
参考文献
GENERICS [UK] LIMITED; MYLAN DEVELOPMENT CENTRE PRIVATE LIMITED
Patent: WO2009/147430 A1, 2009 ;
Location in patent: Page/Page column 14 ;
water in dimethyl sulfoxide T=30°C; pH=7; 18 h; aq. phosphate bufferMicrobiological reactionEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Leisch, Hannes; Grosse, Stephan; Iwaki, Hiroaki; Hasegawa, Yoshie; Lau, Peter C.K.
Canadian Journal of Chemistry, 2012 , vol. 90, # 1 p. 39 - 45
1: sodium hydroxide / toluene; water / 4.95 h / 20 - 47 °C / Inert atmosphere; Industry scale 2: isopropyl alcohol; water / 25 °C / Reflux; Inert atmosphere; Industry scale; Resolution of racemate 3: sodium hydroxide / toluene; water / 40 - 47 °C / Industry scale; Inert atmosphere View Scheme
