2-(4-氟苯基)咪唑并[1,2-a]吡啶合成路线 （共 20 条）
反应条件
sodium carbonate; 1-n-butyl-3-methylimidazolium tetrafluoroborate T=25°C; 1 h;
参考文献
Xie, Yuan-Yuan; Chen, Zhen-Chu; Zheng, Qin-Guo
Journal of Chemical Research - Part S, 2003 , # 10 p. 614 - 615
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in 1,4-dioxane; water T=100°C; Suzuki-Miyaura coupling; 1 h; Inert atmosphereSealed vessel;
参考文献
Marhadour, Sophie; Marchand, Pascal; Pagniez, Fabrice; Bazin, Marc-Antoine; Picot, Carine; Lozach, Olivier; Ruchaud, Sandrine; Antoine, Maud; Meijer, Laurent; Rachidi, Najma; Le Pape, Patrice
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 543 - 556
反应条件
1: 1-fluoro-4-acetyl-benzene With [Bmim]Br3 in neat (no solvent) T=30°C; 0.0833333 h; 2: 2-aminopyridine With sodium carbonate in neat (no solvent) T=30°C; 0.666667 h;
参考文献
Le, Zhang-Gao; Xie, Zong-Bo; Xu, Jian-Ping
Molecules, 2012 , vol. 17, # 11 p. 13368 - 13375
反应条件
copper(l) iodide; lithium carbonate in N,N-dimethyl-formamide T=95°C; 2 h;
参考文献
Huang, Huawen; Ji, Xiaochen; Tang, Xiaodong; Zhang, Min; Li, Xianwei; Jiang, Huanfeng
Organic Letters, 2013 , vol. 15, # 24 p. 6254 - 6257
反应条件
sodium carbonate; 1-butylpyridinium tetrafluoroborate T=25°C; 1 h;
参考文献
Xie, Yuan-Yuan; Chen, Zhen-Chu; Zheng, Qin-Guo
Synthesis, 2002 , # 11 p. 1505 - 1508
反应条件
copper(l) iodide; oxygen in N,N-dimethyl-formamide T=110°C; P=760.051 Torr; 36 h; Schlenk techniqueSealed tubeGreen chemistry;
参考文献
Yu, Jipan; Jin, Yunhe; Zhang, Hao; Yang, Xiaobo; Fu, Hua
Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16804 - 16808
反应条件
copper(II) bis(trifluoromethanesulfonate) in 1,2-dichloro-ethane T=80°C; 2.5 h;
参考文献
Yadav; Subba Reddy; Gopal Rao; Srinivas; Narsaiah
Tetrahedron Letters, 2007 , vol. 48, # 43 p. 7717 - 7720
反应条件
1: 2-aminopyridine-N-oxide With trifluoroacetic acid in dichloromethane 0.166667 h; 2: 1-ethynyl-4-fluorobenzene With dichloro(pyridine-2-carboxylato)gold(III) in dichloromethane T=40°C; 15 h; regioselective reaction;
参考文献
Talbot, Eric P. A.; Richardson, Melodie; McKenna, Jeffrey M.; Toste, F. Dean
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 4 p. 687 - 691
反应条件
1: 6-bromo-2-(4-fluoropjhenyl)imidazo[1,2-a]pyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With zinc(II) chloride in tetrahydrofuran; hexane T=-78°C; 1 h; 3: iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane Negishi-cross-coupling reaction; 16 h; Heating;
参考文献
Helvetica Chimica Acta, , vol. 86, # 10 p. 3461 - 3469
反应条件
potassium carbonate in chloroform 2 h; Heating;
参考文献
Liu, Zhi; Chen, Zhen-Chu; Zheng, Qin-Guo
Synthetic Communications, 2004 , vol. 34, # 2 p. 361 - 367
