3-(3-氟-4-甲氧基苯甲酰)丙酸合成路线 (共 3 条)
反应条件
1: in dichloromethane 0.333333 h; Cooling with ice; 2: With AlCl3, aluminium chloride in dichloromethane T=20 - 65°C;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2012/15942 A1, 2012 ;
Location in patent: Page/Page column 56 ;
US 20120015942 A1
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 7 h;
参考文献
EP2168959 A1, ;
Page/Page column 171 ;
反应条件
potassium hydroxide; hydrazine hydrate; diethylene glycol
参考文献
Buu-Hoi et al.
Journal of Organic Chemistry, 1957 , vol. 22, p. 193,195