4'-氟-2-苯基苯乙酮合成路线 （共 18 条）
反应条件
sodium hydroxide; sodium tetrahydroborate 1.) AcOH, RT, 2.) MeOH, 0 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Chemical Research, Miniprint, , # 2 p. 689 - 697
参考文献
Yuki Gosei Kagaku Kyokaishi, , vol. 17, p. 777,779
Chem.Abstr., , p. 4492
反应条件
in dimethyl sulfoxide T=120°C;
参考文献
Wagner, Peter J.; Zhou, Boli; Hasegawa, Tadashi; Ward, Donald L.
Journal of the American Chemical Society, 1991 , vol. 113, # 25 p. 9640 - 9654
反应条件
hydrogen bromide; bromine; acetic acid in dichloromethane T=26°C; Product distribution / selectivity;
参考文献
VIJAYASRI ORGANICS LIMITED; SRIVATSAVAYI, Jagapathi Raju; POTHUKUCHI, Sairam; RANI, Srinivasa Sastry; CHIKKA, Mallikarjuna Rao; CHEEKATI, Chiranjeevi; GUTTI, Mallikarjuna Rao; SINGAVARAPU, Trimurthulu; THIMMAIPALLY , Venkat Reddy; TADANKI, Venkateswara Rao
Patent: WO2012/143933 A1, 2012 ;
Location in patent: Page/Page column 13-14 ;
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-25 - -10°C; 0.5 h; 2: 1-(4-fluorophenyl)-2-phenyl-1-ethanone in tetrahydrofuran; hexane T=-78 - -60°C; 1 h; 3: 2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide in tetrahydrofuran; hexane T=-78 - 15°C; 1.5 h;
参考文献
BIOCON LIMITED
Patent: WO2004/108660 A1, 2004 ;
Location in patent: Page 5 ;
反应条件
1: sulfuryl dichloride / dichloromethane / 10 - 20 °C 2: potassium carbonate / acetone / 25 - 60 °C / Reflux View Scheme
参考文献
VIJAYASRI ORGANICS LIMITED; SRIVATSAVAYI, Jagapathi Raju; POTHUKUCHI, Sairam; RANI, Srinivasa Sastry; CHIKKA, Mallikarjuna Rao; CHEEKATI, Chiranjeevi; GUTTI, Mallikarjuna Rao; SINGAVARAPU, Trimurthulu; THIMMAIPALLY , Venkat Reddy; TADANKI, Venkateswara Rao
Patent: WO2012/143933 A1, 2012 ;
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran
T=0°C; 0.5 h;
2: With rac-camphorsulfonyloxaziridine in tetrahydrofuran
T=0 - 20°C;
参考文献
DONG-A PHARM.CO., LTD.
Patent: WO2009/84827 A2, 2009 ;
Location in patent: Page/Page column 5; 8 ;
反应条件
sulfuryl dichloride in dichloromethane
T=10 - 20°C;
参考文献
VIJAYASRI ORGANICS LIMITED; SRIVATSAVAYI, Jagapathi Raju; POTHUKUCHI, Sairam; RANI, Srinivasa Sastry; CHIKKA, Mallikarjuna Rao; CHEEKATI, Chiranjeevi; GUTTI, Mallikarjuna Rao; SINGAVARAPU, Trimurthulu; THIMMAIPALLY , Venkat Reddy; TADANKI, Venkateswara Rao
Patent: WO2012/143933 A1, 2012 ;
Location in patent: Page/Page column 19-20 ;
