2-(4-氟苯基)苯乙酮合成路线 （共 22 条）
反应条件
aluminium trichloride T=50°C; Friedel-Crafts arylation; 8 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/56004 A1, 2005 ;
Location in patent: Page/Page column 142 ;
反应条件
magnesium in benzonitrile
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5091378 A1, 1992 ;
US 5091378 A
反应条件
FibreCatTM 1000-D7; sodium t-butanolate in tetrahydrofuran T=85°C; 6 h;
参考文献
Churruca, Fatima; SanMartin, Raul; Carril, Monica; Tellitu, Imanol; Dominguez, Esther
Tetrahedron, 2004 , vol. 60, # 10 p. 2393 - 2408
反应条件
palladium diacetate; 1,4-di(diphenylphosphino)-butane; zinc in 1,4-dioxane T=100°C; Negishi coupling reaction; P=7500.75 Torr; 16 h; Inert atmosphereAutoclave;
参考文献
Wu, Xiao-Feng; Schranck, Johannes; Neumann, Helfried; Beller, Matthias
Chemistry - An Asian Journal, 2012 , vol. 7, # 1 p. 40 - 44
反应条件
1: 4-bromomethyl-fluorobenzene With manganese in tetrahydrofuran T=20°C; Metallation; 0.333333 h; 2: benzoyl chloride in tetrahydrofuran T=20°C; Substitution; 2 h;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2322 - 2330
反应条件
[NiCl2(1,2-dimethoxyethane)]; 1,3-bis-(diphenylphosphino)propane; water; zinc in ethylene glycol dimethyl ether T=100°C; 36 h;
参考文献
Hsieh, Jen-Chieh; Chen, Yen-Chung; Cheng, An-Yi; Tseng, Hsiao-Chun
Organic Letters, 2012 , vol. 14, # 5 p. 1282 - 1285
反应条件
nickel in ethylene glycol dimethyl ether T=85°C; 0.25 h;
参考文献
Inaba, Shin-ichi; Rieke, Reuben D.
Journal of Organic Chemistry, 1985 , vol. 50, # 9 p. 1373 - 1381
反应条件
trans-[1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene]PdCl2(NC5H5); sodium t-butanolate in tetrahydrofuran T=70°C; 9 h; Inert atmosphere;
参考文献
Cao, Changsheng; Wang, Lingling; Cai, Zhengyuan; Zhang, Lingqiao; Guo, Jin; Pang, Guangsheng; Shi, Yanhui
European Journal of Organic Chemistry, 2011 , # 8 p. 1570 - 1574
反应条件
NiBr2bipy; tetra-n-butylammonium tetrafluoroborate T=80°C; Al rod/nickel-sponge, electrolysis;
参考文献
Durandetti, Muriel; Nedelec, Jean-Yves; Perichon, Jacques
Journal of Organic Chemistry, 1996 , vol. 61, # 5 p. 1748 - 1755
反应条件
potassium phosphate; palladium diacetate; tri-cyclo-hexyl-phosphine in water T=80°C; Suzuki carbonylation; P=7500.75 Torr; 20 h; Inert atmosphere;
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
Tetrahedron Letters, 2010 , vol. 51, # 47 p. 6146 - 6149
