4-[(4-甲基苯基)磺酰基]哌啶盐酸盐合成路线 （共 7 条）
反应条件
potassium hydroxide in ethanol; water 4 h; Heating;
参考文献
Itoh; Miyake; Tada; Hirata; Oka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 130 - 151
反应条件
1: 62 percent / NaNO2, CuSO4 / H2O; aq. HCl / 2 h / 0 °C 2: 38 percent / KOH / ethanol; H2O / 4 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 1 p. 130 - 151
反应条件
1: (i) CrO3, aq. AcOH, Ac2O, (ii) aq. HCl 2: (i) aq. HCl, NaNO2, (ii) /BRN= 3587244/ 3: aq. HCl / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 27, p. 70 - 76
反应条件
diazomethyl-trimethyl-silane in methanol; toluene T=20°C; 16 h;
参考文献
Millennium Pharmacuticals, Inc.
Patent: US2012/15943 A1, 2012 ;
Location in patent: Page/Page column 62 ;
US 20120015943 A1
反应条件
in tetrahydrofuran; methanol; dichloromethane
参考文献
Irm LLC
Patent: US2009/75996 A1, 2009 ;
Location in patent: Page/Page column 16-17 ;
参考文献
Yang, Chao; Xia, Wu Jiong; Scheffer, John R.
Tetrahedron, 2007 , vol. 63, # 29 p. 6791 - 6795
反应条件
hydrogenchloride
3 h; Heating;
参考文献
Itoh; Miyake; Tada; Hirata; Oka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 130 - 151
