6-氨基-3,4-二氢-1(2H)-萘酮合成路线 （共 32 条）
反应条件
copper(II) sulfate; sodium nitrite in hydrogenchloride; water T=0°C; 2 h;
参考文献
Itoh; Miyake; Tada; Hirata; Oka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 130 - 151
反应条件
(i) aq. HCl, NaNO2, (ii) /BRN= 3587244/; Multistep reaction;
参考文献
Allinger,N.L.; Jones,E.S.
Journal of Organic Chemistry, 1962 , vol. 27, p. 70 - 76
参考文献
May and Baker Ltd.
Patent: FR1534547 , 1968 ;
Chem.Abstr., 1970 , vol. 72, # 66703
参考文献
WO2008/76336 A2, ;
Page/Page column 78 ;
WO 2008/076336 A2
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite T=0 - 20°C;
参考文献
Cui, Li-Qian; Dong, Zhi-Lei; Liu, Kai; Zhang, Chi
Organic Letters, 2011 , vol. 13, # 24 p. 6488 - 6491
反应条件
1: With hydrogen bromide T=0°C; 2: With hydrogen bromide; copper(I) bromide; sodium nitrite in water T=0 - 20°C;
参考文献
Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Suijkerbuijk, Bart M.J.M.; Menard, Delphine; Zambon, Alfonso; Davies, Lawrence; Pons, Jean-Francois; Whittaker, Steven; Marais, Richard; Springer, Caroline J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1284 - 1304
反应条件
hydrogenchloride; sodium tetrafluoroborate; sodium nitrite
参考文献
Cui, Li-Qian; Dong, Zhi-Lei; Liu, Kai; Zhang, Chi
Organic Letters, 2011 , vol. 13, # 24 p. 6488 - 6491
反应条件
in ethanol T=20°C; 3 h;
参考文献
Valeant Pharmaceuticals North America
Patent: US2008/146661 A1, 2008 ;
Location in patent: Page/Page column 24 ;
US 20080146661 A1
反应条件
sodium carbonate in methanol T=62°C; 18 h;
参考文献
BARBOSA, Joseph; CARSON, Kenneth Gordon; GARDYAN, Michael Walter; HEALY, Jason Patrick; HAN, Qiang; MABON, Ross; PABBA, Praveen; TARVER, JR., James; TERRANOVA, Kristen M.; TUNOORI, Ashok; XU, Xiaolian
Patent: US2012/302562 A1, 2012 ;
Location in patent: Page/Page column 21 ;
US 20120302562 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=40 - 45°C; 24 h;
参考文献
Cui, Li-Qian; Dong, Zhi-Lei; Liu, Kai; Zhang, Chi
Organic Letters, 2011 , vol. 13, # 24 p. 6488 - 6491
