6-氨基-3,4-二氢-1(2H)-萘酮合成路线 （共 32 条）
反应条件
1.1: sodium nitrite; hydrogen bromide / water / 1 h / 5 °C
1.2: 3 h / 20 °C
2.1: bromine; hydrogen bromide / dichloromethane / 2 h / 20 °C
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参考文献
PRESIDIO PHARMACEUTICALS, INC.; LI, Leping; ZHONG, Min
Patent: WO2011/150243 A1, 2011 ;
WO 2011/150243 A1
反应条件
1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 60 °C / Inert atmosphere
2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 105 °C / Inert atmosphere
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参考文献
BARBOSA, Joseph; CARSON, Kenneth Gordon; GARDYAN, Michael Walter; HEALY, Jason Patrick; HAN, Qiang; MABON, Ross; PABBA, Praveen; TARVER, JR., James; TERRANOVA, Kristen M.; TUNOORI, Ashok; XU, Xiaolian
Patent: US2012/302562 A1, 2012 ;
US 20120302562 A1
