2-氨基-6,7,8,9-四氢-5H-苯并环庚烯-5-酮合成路线 （共 5 条）
反应条件
1: With polyphosphoric acid T=0 - 100°C; 3 h; 2: With sodium hydroxide; water T=0 - 35°C; pH=3 - 4;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249583 A1, 2007 ;
Location in patent: Page/Page column 77 ;
US 20070249583 A1
反应条件
1: H2 / Pd-C / acetic acid 2: (i) P2O5, H3PO4, (ii) aq. HCl View Scheme
参考文献
Allinger,N.L.; Jones,E.S.
Journal of Organic Chemistry, 1962 , vol. 27, p. 70 - 76
反应条件
hydrogen bromide 2 h; Heating;
参考文献
Giardina; Clarke; Dondio; Petrone; Sbacchi; Vecchietti
Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3482 - 3491
反应条件
1: With isopentyl nitrite; copper dichloride in acetonitrile T=65°C; 1.2 h; 2: With hydrogenchloride in water; acetonitrile
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249583 A1, 2007 ;
Location in patent: Page/Page column 93 ;
US 20070249583 A1
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite in water T=0°C; 1 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 21 p. 3482 - 3491
