3-羟基-5,5-二甲基环己-2-烯-1-酮合成路线 （共 39 条）
反应条件
in water var. solvents and temp.; Equilibrium constant;
参考文献
Mills, Sander G.; Beak, Peter
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1216 - 1224
反应条件
1: triethylamine, 4-(dimethylamino)pyridine 2: 63 percent / hydroxylamine / benzene 3: 44 percent / hydroxylamine / benzene / reflux, 1 h, r.t., overnight 4: molybdenum hexacarbonyl / acetonitrile; H2O / 2 h / Heating View Scheme
参考文献
Anderson-McKay, Janet; Savage, G. Paul; Simpson, Gregory W.
Australian Journal of Chemistry, 1996 , vol. 49, # 1 p. 163 - 166
反应条件
tetrachloromethane; triphenylphosphine
参考文献
F. HOFFMANN-LA ROCHE AG; CHEN, Li; LIN, Xianfeng; QIU, Zongxing; TANG, Guozhi; WANG, Lisha; WU, Jim Zhen; YANG, Wengang
Patent: WO2011/95576 A1, 2011 ;
Location in patent: Page/Page column 58-59 ;
反应条件
hydrogenchloride; potassium hydroxide; sodium hydroxide 1) MeOH, RT, 2 days, 2) overnight; Yield given. Multistep reaction;
参考文献
Nagarajan, Kuppuswamy; Talwalker, Purnachard K.; Goud, A. Nagana; Shah, Rashmi K.; Shenoy, Sharada J.; Desai, Narasimha D.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 1113 - 1123
反应条件
hydrogenchloride; potassium hydroxide 1) RT, overnight, 2) 15 h; Yield given. Multistep reaction;
参考文献
Nagarajan, Kuppuswamy; Talwalker, Purnachard K.; Goud, A. Nagana; Shah, Rashmi K.; Shenoy, Sharada J.; Desai, Narasimha D.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 1113 - 1123
反应条件
acetic acid in acetonitrile
14 h; Heating;
参考文献
Singh, Kamaljit; Singh, Jasbir; Singh, Harjit
Tetrahedron, 1996 , vol. 52, # 45 p. 14273 - 14280
反应条件
1: AcOH / propan-2-ol / 0.67 h / Heating
2: propan-2-ol / Heating
View Scheme
参考文献
Kolos; Yurchenko; Orlov; Shishkina; Shishkin
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 12 p. 1550 - 1559
反应条件
in diethyl ether; ethyl acetate
4 h; Heating;
参考文献
Edafiogho; Hinko; Chang; Moore; Mulzac; Nicholson; Scott
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2798 - 2805
反应条件
ammonium acetate in acetic acid
Hansch reaction; 2.5 h; Heating;
参考文献
Dzvinchuk; Tolmacheva
Chemistry of Heterocyclic Compounds, 2001 , vol. 37, # 4 p. 506 - 508
反应条件
1: 90 percent / ammonium acetate / ethanol / 4 h / 85 - 90 °C
2: 85 percent / acetic acid / 1 h / Heating
View Scheme
参考文献
Dzvinchuk; Tolmacheva
Chemistry of Heterocyclic Compounds, 2001 , vol. 37, # 4 p. 506 - 508
