4-氯-2-吗啉嘧啶-5-羧酸乙酯合成路线 （共 3 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 0.333333 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/42519 A1, 2005 ;
Location in patent: Page/Page column 41 ;
WO 2005/042519 A1
反应条件
1: sodium acetate / N,N-dimethyl-formamide / 18 h / 110 °C 2: trichlorophosphate / 1.5 h / 90 °C / Cooling with ice View Scheme
参考文献
WO2012/3264 A1, ;
WO 2012/003264 A1
反应条件
1: sodium methylate / methanol / 4 h 2: trichlorophosphate / 3 h / |Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 21 p. 6756 - 6761
