6-苯基-3(2H)-哒嗪酮-4-羧酸乙酯合成路线 （共 5 条）
反应条件
bromine in acetic acid
参考文献
Wermuth; Schlewer; Bourguignon; Maghioros; Bouchet; Moire; Kan; Worms; Biziere
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 528 - 537
反应条件
hydraziniumdihydrochloride in ethanol 18 h; Heating;
参考文献
Coudert; Albuisson; Boire; Duroux; Bastide; Couquelet
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 6 p. 471 - 477
反应条件
1: 60 percent / hydrazine hydrate / ethanol / Ambient temperature 2: 60 percent / bromine / acetic acid View Scheme
参考文献
Wermuth; Schlewer; Bourguignon; Maghioros; Bouchet; Moire; Kan; Worms; Biziere
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 528 - 537
反应条件
ammonium hydroxide
T=20°C;
参考文献
Wermuth; Schlewer; Bourguignon; Maghioros; Bouchet; Moire; Kan; Worms; Biziere
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 528 - 537
反应条件
1: 68 percent / NH3 / methanol / Ambient temperature; overnight
2: 80 percent / bromine, NaOH / H2O / 1. 0 degC, 30min., then steam bath, 3h
View Scheme
参考文献
Sircar
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 6 p. 1473 - 1476
