(7S)-7-氨基-1,2,3,10-四甲氧基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮合成路线 （共 42 条）
反应条件
1: (COCl)2; DMSO; Et3N 3: 64 percent / PPh3; DEAD; (PhO)2P(O)N3 4: Ph3P; H2O 5: Et3N 6: 70 percent / 1,2-dichloro-benzene / Heating 7: LiOH 9: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 10: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 11: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: Ph3P; H2O 2: Et3N 3: 70 percent / 1,2-dichloro-benzene / Heating 4: LiOH 6: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 7: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 8: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: Et3N 2: 70 percent / 1,2-dichloro-benzene / Heating 3: LiOH 5: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 6: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 7: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: 64 percent / PPh3; DEAD; (PhO)2P(O)N3 2: Ph3P; H2O 3: Et3N 4: 70 percent / 1,2-dichloro-benzene / Heating 5: LiOH 7: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 8: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 9: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: LiOH 3: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 4: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 5: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: 70 percent / 1,2-dichloro-benzene / Heating 2: LiOH 4: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 5: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 6: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 2: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 3: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: TBAF / tetrahydrofuran 2: (COCl)2; DMSO; Et3N 4: (COCl)2; DMSO; Et3N 6: 64 percent / PPh3; DEAD; (PhO)2P(O)N3 7: Ph3P; H2O 8: Et3N 9: 70 percent / 1,2-dichloro-benzene / Heating 10: LiOH 12: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 13: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 14: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 2: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: 79 percent / Na2CO3 / diethyl ether / 2.5 h / Ambient temperature 2: 46 percent / methanol; diethyl ether / 3 h 3: 70 percent / K2CO3 / acetone; H2O / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 13 p. 2515 - 2521
