(E)-3-二甲基氨基-1-噻吩-2-丙酮合成路线 （共 11 条）
反应条件
in xylene T=130°C; 48 h; Heating / reflux;
参考文献
NIPPON KAYAKU KABUSHIKI KAISHA
Patent: EP1674454 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
N,N-dimethyl-formamide dimethyl acetal in toluene
参考文献
Neurocrine Biosciences, Inc.
Patent: EP1206248 B1, 2003 ;
反应条件
N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
Chen, Shao-Rui; Li, Ai-Jun; Chen, Ming-Ming
Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1680 - 1684
反应条件
sodium in ethanol 16 h; Reflux;
参考文献
Bolduc, Andreanne; Dufresne, Stephane; Hanan, Garry S.; Skene
Canadian Journal of Chemistry, 2010 , vol. 88, # 3 p. 236 - 246
反应条件
potassium hydroxide; hydroxylamine hydrochloride in ethanol; water Reflux;
参考文献
Al-Qalaf, Fawzia; Mandani, Faisal; Abdelkhalik, Mervat Mohammed; Bassam, Abeer Abdulrahman
Molecules, 2009 , vol. 14, # 1 p. 78 - 88
反应条件
acetic acid T=110°C; 1 h;
参考文献
Baraldi, Pier Giovanni; Fruttarolo, Francesca; Tabrizi, Mojgan Aghazadeh; Romagnoli, Romeo; Preti, Delia; Ongini, Ennio; El-Kashef, Hussein; Carrion, Maria Dora; Borea, Pier Andrea
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 2 p. 355 - 361
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 8 h; Reflux;
参考文献
Chen, Shao-Rui; Li, Ai-Jun; Chen, Ming-Ming
Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1680 - 1684
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux 2.1: potassium hydroxide / 0.5 h / 20 °C 2.2: 12 h / 90 °C View Scheme
参考文献
Chen, Shao-Rui; Li, Ai-Jun; Chen, Ming-Ming
Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1680 - 1684
反应条件
(1S)-10-camphorsulfonic acid in toluene T=100°C; 1.5 h; Heating / reflux;
参考文献
NIPPON KAYAKU KABUSHIKI KAISHA
Patent: EP1674454 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
hydrazine hydrate in ethanol 3 h; Heating;
参考文献
Al-Omran, Fatima; Al-Awadi, Nouria; El-Khair, Adel Abou; Elnagdi, Mohammed Hilmy
Organic Preparations and Procedures International, 1997 , vol. 29, # 3 p. 285 - 292
