1-(5-溴噻吩-2-基)-2,2,2-三氟乙酮合成路线 （共 3 条）
反应条件
Dess-Martin periodane in dichloromethane T=20°C; Dess-Martin oxidation; 3 h;
参考文献
Ontoria, Jesus M.; Altamura, Sergio; Di Marco, Annalise; Ferrigno, Federica; Laufer, Ralph; Muraglia, Ester; Palumbi, Maria Cecilia; Rowley, Michael; Scarpelli, Rita; Schultz-Fademrecht, Carsten; Serafini, Sergio; Steinkuehler, Christian; Jones, Philip
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6782 - 6789
反应条件
1.1: pyridine / dichloromethane / 0 - 20 °C 2.1: cesium fluoride / toluene / 0.17 h / 0 °C 2.2: 24 h / 0 - 20 °C 3.1: tetrabutyl ammonium fluoride; water / toluene; tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Rudzinski, Diandra M.; Kelly, Christopher B.; Leadbeater, Nicholas E.
Chemical Communications, 2012 , vol. 48, # 77 p. 9610 - 9612
反应条件
1.1: cesium fluoride / toluene / 0.17 h / 0 °C 1.2: 24 h / 0 - 20 °C 2.1: tetrabutyl ammonium fluoride; water / toluene; tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Rudzinski, Diandra M.; Kelly, Christopher B.; Leadbeater, Nicholas E.
Chemical Communications, 2012 , vol. 48, # 77 p. 9610 - 9612
