6-甲氧基-4-氧代-1,4-二氢喹啉-3-羧酸合成路线 （共 8 条）
反应条件
sodium hydroxide 1 h; Heating;
参考文献
Neurogen Corporation
Patent: US6413956 B1, 2002 ;
US 6413956 B1
反应条件
sodium hydroxide in water T=80°C; Hydrolysis; 0.5 h;
参考文献
Mohri, Kunihiko; Kanie, Akihiko; Horiguchi, Yoshie; Isobe, Kimiaki
Heterocycles, 1999 , vol. 51, # 10 p. 2377 - 2384
反应条件
1: various solvent(s) / 1 h / Heating 2: aq. NaOH / 1 h / Heating View Scheme
参考文献
Golub, Andriy G.; Yakovenko, Olexander Ya.; Bdzhola, Volodymyr G.; Sapelkin, Vladislav M.; Zien, Piotr; Yarmoluk, Sergiy M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6443 - 6450
反应条件
1: 1 h / Heating 2: various solvent(s) / 1 h / Heating 3: aq. NaOH / 1 h / Heating View Scheme
参考文献
Mohri, Kunihiko; Kanie, Akihiko; Horiguchi, Yoshie; Isobe, Kimiaki
Heterocycles, 1999 , vol. 51, # 10 p. 2377 - 2384
反应条件
1: 58 percent / tetrahydrofuran; diethyl ether / 20 °C 2: 64 percent / diphenyl ether / 0.5 h / 230 °C 3: 79 percent / NaOH / H2O / 1 h / 60 °C 4: 0.33 h / 180 °C / heating with powdered glass 5: NaOH / H2O / 0.5 h / 80 °C View Scheme
参考文献
Mohri, Kunihiko; Kanie, Akihiko; Horiguchi, Yoshie; Isobe, Kimiaki
Heterocycles, 1999 , vol. 51, # 10 p. 2377 - 2384
反应条件
1: 79 percent / NaOH / H2O / 1 h / 60 °C 2: 0.33 h / 180 °C / heating with powdered glass 3: NaOH / H2O / 0.5 h / 80 °C View Scheme
参考文献
Mohri, Kunihiko; Kanie, Akihiko; Horiguchi, Yoshie; Isobe, Kimiaki
Heterocycles, 1999 , vol. 51, # 10 p. 2377 - 2384
反应条件
1: 0.33 h / 180 °C / heating with powdered glass 2: NaOH / H2O / 0.5 h / 80 °C View Scheme
参考文献
Mohri, Kunihiko; Kanie, Akihiko; Horiguchi, Yoshie; Isobe, Kimiaki
Heterocycles, 1999 , vol. 51, # 10 p. 2377 - 2384
反应条件
1: 64 percent / diphenyl ether / 0.5 h / 230 °C 2: 79 percent / NaOH / H2O / 1 h / 60 °C 3: 0.33 h / 180 °C / heating with powdered glass 4: NaOH / H2O / 0.5 h / 80 °C View Scheme
参考文献
Mohri, Kunihiko; Kanie, Akihiko; Horiguchi, Yoshie; Isobe, Kimiaki
Heterocycles, 1999 , vol. 51, # 10 p. 2377 - 2384
