4-甲基喹唑啉-2(3h)-酮合成路线 （共 6 条）
反应条件
ammonium acetate in dimethyl sulfoxide
参考文献
Arienzo, Rosa; Cramp, Sue; Dyke, Hazel J.; Lockey, Peter M.; Norman, Dennis; Roach, Alan G.; Smith, Phil; Wong, Melanie; Wren, Stephen P.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1403 - 1407
反应条件
1: methylmagnesium bromide; 2-amino-benzonitrile in diethyl ether T=20°C; 2 h; Heating / reflux; 2: methyl chloroformate in tetrahydrofuran; diethyl ether T=0°C; Heating / reflux;
参考文献
SENOMYX, INC.
Patent: US2008/306053 A1, 2008 ;
Location in patent: Page/Page column 68 ;
反应条件
1: With trifluorormethanesulfonic acid in 1,2-dichloro-ethane Reflux; 2: With sodium hydrogencarbonate in water; ethyl acetate; 1,2-dichloro-ethane
参考文献
Wang, Honggen; Liu, Lanying; Wang, Yong; Peng, Changlan; Zhang, Jiancun; Zhu, Qiang
Tetrahedron Letters, 2009 , vol. 50, # 49 p. 6841 - 6843
反应条件
in hydrogenchloride; water; acetic acid
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6200976 B1, 2001 ;
US 6200976 B1
反应条件
1: 93 percent / DMAP 2: 65 percent / NH4OAc / dimethylsulfoxide View Scheme
参考文献
Zhao, Dan; Wang, Teng; Shen, Qi; Li, Jian-Xin
Chemical Communications, 2014 , vol. 50, # 33 p. 4302 - 4304
反应条件
trichlorophosphate in hydrogenchloride
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6200976 B1, 2001 ;
US 6200976 B1
