(2-氨基嘌呤-6-基)三甲基氯化铵合成路线 (共 3 条)
反应条件
1: 3-fluorobenzyl alcohol With sodium hydride in dimethyl sulfoxide T=20°C; 1 h; 2: 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride in dimethyl sulfoxide
参考文献
Liu, Xuan; Zheng, Qi-Huang; Hutchins, Gary D.; Fei, Xiangshu; Erickson, Leonard C.; Miller, Kathy D.; Mock, Bruce H.; Glick-Wilson, Barbara E.; Winkle, Wendy L.; Stone, K. Lee; Carlson, Kathy A.
Synthetic Communications, 2003 , vol. 33, # 6 p. 941 - 952
反应条件
benzyl alcohol in dimethyl sulfoxide Ambient temperature;
参考文献
MacCoss, Malcolm; Chen, Anna; Tolman, Richard L.
Tetrahedron Letters, 1985 , vol. 26, # 15 p. 1815 - 1818
反应条件
1: (4-bromo-thiophen-2-yl)-methanol With sodium hydride; dimethyl sulfoxide 1 h; 2: 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride in dimethyl sulfoxide 1 h; Further stages.;
参考文献
Reinhard; Hull; Von der Lieth; Eichhorn; Kliem; Kaina; Wiessler
Journal of Medicinal Chemistry, 2001 , vol. 44, # 24 p. 4050 - 4061