反应条件
1: 76 percent / I2, NaHCO3 / H2O / 3 h / 60 °C
2: 88 percent / pyridine / CHCl3 / 1.) room temp., 0.5 h, 2.) 50-60 deg C, 2 h
3: 64 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C
4: 95 percent / SnCl2, HCl / diethyl ether; CH2Cl2 / 2 h
5: 1.) Mg / 1.) diethyl ether, 30 min, 2.) THF, diethyl ether, overnight, reflux
6: CrO3, conc. H2SO4 / acetone; H2O
7: 85 percent / conc. HCl / H2O / 1 h / Heating
8: 64.4 percent / I2, HgO / acetic acid / 1 h / Ambient temperature
View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
