1: diisopropylamine in tetrahydrofuran Cooling with acetone-dry ice; 2: n-butyllithium in hexane 0.25 h; 3: 2,4-difluoro-1-bromobenzene; methyl iodide more than 3 stages;
参考文献
The Procter and Gamble Co.
Patent: US6348624 B1, 2002 ;
Location in patent: Page column 11 ;
1: benzyl alcohol With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: 2,4-difluoro-1-bromobenzene in tetrahydrofuran T=20°C; 17 h; Further stages. Title compound not separated from byproducts.;
参考文献
Ouellet, Stephane G.; Bernardi, Anna; Angelaud, Remy; O'Shea, Paul D.
Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3776 - 3779
1: benzyl alcohol With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: 2,4-difluoro-1-bromobenzene in tetrahydrofuran T=20°C; 17 h; Further stages. Title compound not separated from byproducts.;
参考文献
Ouellet, Stephane G.; Bernardi, Anna; Angelaud, Remy; O'Shea, Paul D.
Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3776 - 3779
