4-溴-1,2-二氟苯合成路线

参考文献

Roe et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 28,29

参考文献

Cervena; Sindelar; Kopicova; et al.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 6 p. 2001 - 2017

348-61-84-溴-1,2-二氟苯

325-58-6

参考文献

Roe et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 28,29

348-61-84-溴-1,2-二氟苯

362611-66-3((4S,4as,8ar)-去氢异喹啉-4-基)(4-(3,4-二氟苯基)哌嗪-1-基)甲酮

参考文献

Baenziger, Markus; Cercus, Jacques; Hirt, Hans; Laumen, Kurt; Malan, Christophe; Spindler, Felix; Struber, Fritz; Troxler, Thomas
Tetrahedron Asymmetry, 2003 , vol. 14, # 22 p. 3469 - 3477

348-61-84-溴-1,2-二氟苯

2105-94-44-溴-2-氟苯酚+

112204-58-72-氟-5-溴苯酚

参考文献

Li, Jianqing; Smith, Daniel; Qiao, Jennifer X.; Huang, Stella; Krishnananthan, Subramaniam; Wong, Henry S.; Salvati, Mark E.; Balasubramanian, Balu N.; Chen, Bang-Chi
Synlett, 2009 , # 4 p. 633 - 637

348-61-84-溴-1,2-二氟苯

255893-57-31-(3,4-二氟苯基)哌嗪

参考文献

BAYER HEALTHCARE AG
Patent: WO2004/96778 A1, 2004 ;
Location in patent: Page/Page column 31 ;

110-85-0哌嗪+

348-61-84-溴-1,2-二氟苯

255893-57-31-(3,4-二氟苯基)哌嗪

参考文献

Neustadt, Bernard R.; Hao, Jinsong; Lindo, Neil; Greenlee, William J.; Stamford, Andrew W.; Tulshian, Deen; Ongini, Ennio; Hunter, John; Monopoli, Angela; Bertorelli, Rosalia; Foster, Carolyn; Arik, Leyla; Lachowicz, Jean; Ng, Kwokei; Feng, Kung-I
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1376 - 1380

78-82-0异丁腈+

348-61-84-溴-1,2-二氟苯

749928-77-62-(4-溴-2-氟苯基)-2-甲基丙腈

参考文献

Wyeth
Patent: US2006/247441 A1, 2006 ;
Location in patent: Page/Page column 16 ;

348-61-84-溴-1,2-二氟苯+

25015-63-8频哪醇硼烷

754226-39-62-(3,4-二氟苯基)-4,4,5,5-四甲基-1,3,2-二噁硼烷

参考文献

Pintaric, Christine; Olivero, Sandra; Gimbert, Yves; Chavant, Pierre Y.; Dunach, Elisabet
Journal of the American Chemical Society, 2010 , vol. 132, # 34 p. 11825 - 11827

348-61-84-溴-1,2-二氟苯

754226-39-62-(3,4-二氟苯基)-4,4,5,5-四甲基-1,3,2-二噁硼烷

参考文献

Takagi, Jun; Yamakawa, Tetsu
Tetrahedron Letters, 2013 , vol. 54, # 2 p. 166 - 169