1-[4-氯-3-(三氟甲基)苯基]-1-乙醇合成路线 （共 3 条）
反应条件
methyl-magnesium chloride in tetrahydrofuran; diethyl ether T=-78 - -20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/101970 A1, 2003 ;
Location in patent: Page 10-11 ;
WO 03/101970 A1
反应条件
1: in tetrahydrofuran; diethyl ether T=-78°C; Inert atmosphere; 2: With ammonium chloride in tetrahydrofuran; diethyl ether
参考文献
PIERRE FABRE MEDICAMENT; PEREZ, Michel; LAMOTHE, Marie; JUNQUERO, Didier; RIVAL, Yves
Patent: WO2010/100139 A1, 2010 ;
Location in patent: Page/Page column 102 ;
WO 2010/100139 A1
反应条件
oxalyl dichloride; triethylamine in dichloromethane; dimethyl sulfoxide T=-78°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/101970 A1, 2003 ;
Location in patent: Page 10-11 ;
WO 03/101970 A1
