3,4-二-O-乙酰-1,5-酐-2,6-双脱氧-L-阿拉伯-己-1-糖醇合成路线 （共 35 条）
反应条件
1: mercuric sulfate, 5 mM aq. H2SO4 / acetone / 5 h / Ambient temperature
2: CH2Cl2 / 2 h / 0 °C
3: 78 percent / pyridine, 4-dimethylaminopyridine / CH2Cl2 / 3 h / 20 °C
4: 54 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.25 h / -35 °C
View Scheme
参考文献
Lau; Pedersen; Nielsen
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1991 , vol. 45, # 6 p. 616 - 620
反应条件
methanol; potassium carbonate
T=20°C; 24 h;
参考文献
Dixon, John T.; Van Heerden, Fanie R.; Holzapfel, Cedric W.
Tetrahedron Asymmetry, 2005 , vol. 16, # 2 p. 393 - 401
反应条件
sodium methylate
1) methanol, 6.5 h, benzene; 2) pyridine, -35 deg C, 2 h; 25 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Paquette, Leo A.; Oplinger, Jeffrey A.
Tetrahedron, 1989 , vol. 45, # 1 p. 107 - 124
反应条件
1: H2O / 80 °C
2: glacial acetic acid; sodium azide / H2O / 20 °C
3: pyridine; 4-dimethylaminopyridine / 20 °C
4: 1.80 g / montmorillonite K-10 / benzene / Heating
5: potassium carbonate / methanol / 16 h / 20 °C
View Scheme
参考文献
Florent, Jean-Claude; Monneret, Claude
Journal of the Chemical Society, Chemical Communications, 1987 , # 15 p. 1171 - 1172
反应条件
1: 2.) sodium azide / 1.) water, 80 deg C, 2 h; 2.) water, acetic acid, r.t., 18 h
2: 88 percent / pyridine / CH2Cl2 / 18 h / Ambient temperature
3: 1.) K10 montmorillonite 2.) 1N NaOMe / 1.) benzene, reflux, 24 h; 2.) methanol, 6 h
View Scheme
参考文献
Abbaci, Belgacem; Florent, Jean-Claude; Monneret, Claude
Bulletin de la Societe Chimique de France, 1989 , # 5 p. 667 - 672
