1,3-二羧甲基-2-甲基-2-硫代异脲合成路线 （共 24 条）
反应条件
sodium hydroxide in water T=0 - 5°C; pH=9;
参考文献
BioCryst Pharmaceuticals, Inc.
Patent: US2004/254181 A1, 2004 ;
Location in patent: Page 16 ;
反应条件
1: 2-methyl-2-thiopseudourea With N,O-bis-(trimethylsilyl)-acetamide in dichloromethane T=20°C; 1.16667 h; 2: methyl chloroformate in dichloromethane 2 h; cooling;
参考文献
Fonseca, Tatiana; Gigante, Barbara; Marques, M. Matilde; Gilchrist, Thomas L.; De Clercq, Erik
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 103 - 112
反应条件
sodium hydroxide; sodium acetate; acetic acid in water
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 2 p. 409 - 417
反应条件
sodium hydroxide 1.) water, reflux, 30 min; 2.) 10 min , 25 degC; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 51, # 39 p. 10771 - 10794
反应条件
toluene-4-sulfonic acid in methanol Heating;
参考文献
Bayer AG
Patent: FR2270861DE2423679 , 19751975 ;
Chem.Abstr., 1976 , vol. 84, # 73949
反应条件
in methanol; di-isopropyl ether; acetic acid
参考文献
Hoechst Aktiengesellschaft
Patent: US4639463 A1, 1987 ;
反应条件
in methanol; water 3 h; Heating;
参考文献
Hazelton; Iddon; Suschitzky; Woolley
Tetrahedron, 1995 , vol. 51, # 39 p. 10771 - 10794
反应条件
in methanol; water 3 h; Heating;
参考文献
Hazelton; Iddon; Suschitzky; Woolley
Tetrahedron, 1995 , vol. 51, # 39 p. 10771 - 10794
反应条件
1: With triethylamine; mercury dichloride in N,N-dimethyl-formamide T=26°C; 2: With sodium acetate in methanol T=0 - 20°C; 3: With sodium hydroxide in methanol; water T=60°C; 0.5 h;
参考文献
HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian
Patent: WO2011/35009 A1, 2011 ;
Location in patent: Page/Page column 74-75 ;
反应条件
acetic acid in methanol
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4076825 A1, 1978 ;
