1,3-二羧甲基-2-甲基-2-硫代异脲合成路线 （共 24 条）
反应条件
in N,N-dimethyl-formamide 3 h; Heating;
参考文献
Agrawal, Vijai K.; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 10 p. 967 - 968
反应条件
in N,N-dimethyl-formamide 3 h; Heating; Yield given;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 967 - 968
反应条件
toluene-4-sulfonic acid in methanol 4 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 10 p. 2297 - 2300
反应条件
in ethanol
5 h; Heating;
参考文献
Naim, S. Shawkat; Singh, Sudhir K.; Sharma, Satyavan; Gupta, Suman; Fatma, N.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 1106 - 1109
反应条件
sodium hydroxide in isopropyl alcohol
Ambient temperature;
参考文献
Weinhardt; Beard; Dvorak; Marx; Patterson; Roszkowski; Schuler; Unger; Wagner; Wallach
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 616 - 627
反应条件
acetic acid in methanol
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4076825 A1, 1978 ;
反应条件
in N,N-dimethyl-formamide
3 h; Heating; Yield given;
参考文献
Agrawal, Vijai K.; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 10 p. 967 - 968
反应条件
in ethanol
5 h; Heating;
参考文献
Agrawal, Vijai K.; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 2 p. 146 - 149
反应条件
in methanol; ethylene glycol dimethyl ether
T=105°C; 12 h;
参考文献
EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
Location in patent: Page/Page column 173 ;
WO 2012/071509 A2
反应条件
hydrogen; nickel
1.) methanol, 2.5 kg/cm3, 3.5 h, 2.) methanol, p-TSA, 8h, reflux; Yield given. Multistep reaction;
参考文献
Akhtar, M. S.; Sharma, V. L.; Seth, M.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 448 - 451
