3-氨基-3-(3,4-二甲氧基-苯基)-丙酸合成路线 (共 9 条)
反应条件
ammonium formate in ethanol 6 h; Reflux;
参考文献
Bea, Han-Seop; Park, Hye-Jeong; Lee, Sang-Hyeup; Yun, Hyungdon
Chemical Communications, 2011 , vol. 47, # 20 p. 5894 - 5896
反应条件
ammonium acetate; malonic acid in ethanol
参考文献
Celgene Corporation
Patent: US5703098 A1, 1997 ;
反应条件
ammonium acetate; malonic acid in ethyl alcohol water
参考文献
THE NUTRASWEET COMPANY, (a Delaware corporation)
Patent: EP355819 A1, 1990 ;
反应条件
16 h; Heating / reflux;
参考文献
CELGENE CORPORATION
Patent: WO2004/45597 A1, 2004 ;
Location in patent: Page/Page column 31-32; 38 ;
反应条件
ammonium acetate in butan-1-ol Rodionov reaction; Heating;
参考文献
Russian Journal of General Chemistry, , vol. 75, # 7 p. 1113 - 1124
反应条件
1: HCl / Heating 2: Et3N, DMAP / CH2Cl2 3: LiOH, H2O / methanol 4: penicillin acylase / various solvent(s) / 12 h / 25 °C View Scheme
参考文献
Bea, Han-Seop; Park, Hye-Jeong; Lee, Sang-Hyeup; Yun, Hyungdon
Chemical Communications, 2011 , vol. 47, # 20 p. 5894 - 5896
反应条件
1: 2) TFAA / 1) r.t., 15 min, 2) reflux, 3 h
2: 78 percent / 6N HCl / 0.5 h / Heating
3: NaNO2 / aq. HCl / 1 h / 60 °C
4: 78 percent / chromic anhydride, H2SO4, H2O / acetone / 1 h / Ambient temperature
View Scheme
参考文献
Dallemagne, P.; Pilo, J. C.; Rault, S.; Robba, M.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, # 1 p. 121 - 124
反应条件
toluene-4-sulfonic acid
24 h; Reflux;
参考文献
Mbatia, Hannah W.; Dhammika Bandara; Burdette, Shawn C.
Chemical Communications, 2012 , vol. 48, # 43 p. 5331 - 5333
反应条件
sodium carbonate in methanol; dichloromethane; water
参考文献
Celgene Corporation
Patent: US5703098 A1, 1997 ;