2-甲氧基-5-硝基苯甲酸甲酯合成路线 （共 20 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; Inert atmosphere;
参考文献
Schmidt, Bernd; Hoelter, Frank; Berger, Rene; Jessel, Soenke
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 14-15 p. 2463 - 2473
反应条件
1: 2-methoxy-5-nitrobenzoic acid With potassium carbonate in N,N-dimethyl-formamide T=80°C; 1 h; 2: methyl iodide in N,N-dimethyl-formamide T=80°C;
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/186692 A1, 2013 ;
Location in patent: Page/Page column 67 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C;
参考文献
Fukai, Ryosuke; Zheng, Xiaoxia; Motoshima, Kazunori; Tai, Akihiro; Yazama, Futoshi; Kakuta, Hiroki
ChemMedChem, 2011 , vol. 6, # 3 p. 550 - 560
反应条件
nitric acid in sulfuric acid T=5°C; 1 h;
参考文献
Paulis, Tomas de; Janowsky, Aaron; Kessler, Robert M.; Clanton, Jeffrey A.; Smith, Howard E.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2027 - 2033
反应条件
1: methanol With thionyl chloride T=0°C; 2: 2-methoxy-5-nitro-benzoic acid sodium salt Reflux;
参考文献
US2014/57911 A1, ;
Paragraph 0280; 0281 ;
反应条件
potassium carbonate in acetone Heating;
参考文献
Morgentin, Remy; Pasquet, Georges; Boutron, Pascal; Jung, Frederic; Lamorlette, Maryannick; Maudet, Mickael; Ple, Patrick
Tetrahedron, 2008 , vol. 64, # 12 p. 2772 - 2782
反应条件
sodium hydride; dimethyl sulfate in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Pfizer Inc.
Patent: US6369074 B1, 2002 ;
Location in patent: Example 20 ;
US 6369074 B1
反应条件
1.1: methanol / 15 h / |Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 2.2: 80 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 67, p. 99,101
Journal of the American Chemical Society, , vol. 64, p. 86,88
反应条件
nitric acid 1.) 11 h, 160 deg C, in a sealed tube, 2.) ether; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 701 - 710
