1.1: 1H-imidazole; dimethyl sulfoxide / 20 °C / Inert atmosphere 2.1: water; lithium hydroxide hydrate / acetonitrile / 4 h / 50 - 60 °C 3.1: triethylamine / acetone / 0.08 h / 0 °C 4.1: sodium azide / acetone / 2 h / 20 °C 5.1: toluene / 2 h / Reflux; Inert atmosphere 6.1: water / 2 h / Reflux 7.1: sodium tetrahydroborate / methanol / 0.17 h / 0 - 20 °C / Inert atmosphere 8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 9.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 30 h / 20 °C 10.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 h / -78 - -40 °C 10.2: 14 h / -40 - 0 °C View Scheme

NADPH; recombinant human CYP2B6 in phosphate buffer T=37°C; pH=7.4; Enzyme kinetics; Further Variations:Catalysts;

Glc 6P; glucose 6-phosphate dehyrogenase; nicotinamide adenine dinucleotide phosphate; magnesium chloride T=37°C; pH=7.4; 0.5 h; aq. phosphate bufferMicrobiological reaction; Kinetics; Reagent/catalystTime;

hydrogen bromide in isopropyl alcohol T=0 - 80°C; 2.33333 h; Heating / reflux;