(S)-(-)-2-甲基-1-苯基-1-丙醇合成路线 （共 40 条）
反应条件
C58H56Cl2N2P2Ru; potassium tert-butylate; hydrogen in isopropyl alcohol T=30°C; P=6080.41 Torr; 10 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Ooka, Hirohito; Arai, Noriyoshi; Azuma, Keita; Kurono, Nobuhito; Ohkuma, Takeshi
Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 9084 - 9093
反应条件
titanium(IV) isopropylate in tetrahydrofuran T=0°C; 0.166667 h;
参考文献
Wu, Kuo-Hui; Gau, Han-Mou
Journal of the American Chemical Society, 2006 , vol. 128, # 46 p. 14808 - 14809
反应条件
lt;lt;(1S,2R)-6,6-dimethylbicyclolt;3.1.1gt;heptan-2-ylgt;methylgt;aluminum dichloride in diethyl ether 4 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Giacomelli, Giampaolo; Lardicci, Luciano; Palla, Fabio
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 310 - 313
反应条件
1: isopropylmagnesium chloride With sodium methylate; zinc(II) chloride in diethyl ether T=0 - 20°C; Inert atmosphere; 2: benzaldehyde With (S)-N-(3-methyl-1-(1-pyrrolidin-1-yl)butan-2-yl) diphenylphosphinic amideamine T=20°C; Inert atmosphereNeat (no solvent); optical yield given as percent eeenantioselective reaction;
参考文献
Hatano, Manabu; Mizuno, Tomokazu; Ishihara, Kazuaki
Chemical Communications, 2010 , vol. 46, # 30 p. 5443 - 5445
反应条件
chiral 2-(3',5'-di-tert-butylphenyl)-4,4,8-trimethyl-2-phosphabicyclolt;3.3.0gt;octane in n-heptane T=-40°C; 42 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 121, # 24 p. 5813 - 5814
反应条件
1: phenyl-magnesium bromide With Et2AlBr in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: With titanium(IV) isopropylate; [{(R)-H8-BINOLate}Ti(O-i-Pr)2]n in toluene T=0°C; 0.166667 h; Inert atmosphere; 3: isobutyraldehyde Further stages;
参考文献
Zhou, Shuangliu; Wu, Kuo-Hui; Chen, Chien-An; Gau, Han-Mou
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3500 - 3505
反应条件
1: isopropylmagnesium chloride With sodium methylate; zinc(II) chloride in diethyl ether T=0 - 20°C; Inert atmosphere; 2: benzaldehyde With (S)-N-(3-methyl-1-(1-pyrrolidin-1-yl)butan-2-yl) diphenylphosphinic amideamine in diethyl ether T=20°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Chemical Communications, , vol. 46, # 30 p. 5443 - 5445
反应条件
1: With MnIII(L-5-t-Bu)(Cl); 1-butyl-2,6-dimethyl-pyridinium; bromide in dichloromethane; water T=20°C; 2: With [bis(acetoxy)iodo]benzene in dichloromethane; water T=20°C; 0.1 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 20 p. 2359 - 2362
反应条件
(1R,2R,4S,5S)-4,8,8-triMe-2-Ph-2-phosphabicyclo[3.3.0]octane in toluene T=20°C; 1 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 125, # 14 p. 4166 - 4173
反应条件
(R)-5-CF3-2-Ph-2,3-dihydroimidazo[1,2-a]pyridine; N-ethyl-N,N-diisopropylamine in chloroform 30 h; cooling; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 126, # 39 p. 12226 - 12227
