(S)-(-)-2-甲基-1-苯基-1-丙醇合成路线 （共 40 条）
反应条件
Birman's catalyst; nicotinic anhydride in dichloromethane T=0°C; 12 h; Resolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Shiina, Isamu; Nakata, Kenya; Ono, Keisuke; Mukaiyama, Teruaki
Helvetica Chimica Acta, 2012 , vol. 95, # 10 p. 1891 - 1911,21
Title/Abstract Full Text Show Details
Shiina, Isamu; Nakata, Kenya; Ono, Keisuke; Mukaiyama, Teruaki
Helvetica Chimica Acta, 2012 , vol. 95, # 10 p. 1891 - 1911
反应条件
[{(R)-H8-BINOLate}Ti(O-i-Pr)2]x in tetrahydrofuran T=20°C; 0.0166667 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Wu, Kuo-Hui; Zhou, Shuangliu; Chen, Chien-An; Yang, Mao-Chi; Chiang, Ruei-Tang; Chen, Chi-Ren; Gau, Han-Mou
Chemical Communications, 2011 , vol. 47, # 42 p. 11668 - 11670
反应条件
(R)-5-CF3-2-Ph-2,3-dihydroimidazo[1,2-a]pyridine; N-ethyl-N,N-diisopropylamine in chloroform T=0°C; 30 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 126, # 39 p. 12226 - 12227
反应条件
Birman's catalyst; trimethylacetic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Shiina, Isamu; Nakata, Kenya; Sugimoto, Masuhiro; Onda, Yu-Suke; Iizumi, Takashi; Ono, Keisuke
Heterocycles, 2009 , vol. 77, # 2 p. 801 - 810
反应条件
(1S,2R)-(+)-erythro-2-amino-1,2-diphenylethanol; benzoic acid in water; acetonitrile T=20°C;
参考文献
Chemistry - A European Journal, , vol. 13, # 7 p. 2144 - 2152
反应条件
(Rp)-xylyl-PHANEPHOS in chloroform-d1 T=-67 - 25°C; Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 129, # 13 p. 3836 - 3837
反应条件
N-ethyl-N,N-diisopropylamine; CF3-PIP in chloroform T=0°C; 30 - 30.25 h; Resolution of racemate; Product distribution / selectivity;
参考文献
US2005/256150 A1, ;
Page/Page column 15; 16; 18 ;
反应条件
1: isopropyl alcohol With [Ru(1,5-cyclooctadiene)Cl2]x; (8R,9R)-9-amino-(9-deoxy)epiquinine T=20°C; 0.5 h; Inert atmosphere; 2: With potassium hydroxide 0.5 h; Inert atmosphere; 3: 1-phenyl-2-methyl-1-propanone T=0°C; 96 h; Inert atmosphere; enantioselective reaction;
参考文献
Journal of Chemical Research, , vol. 37, # 12 p. 761 - 763
反应条件
1: isopropylmagnesium chloride With sodium methylate; zinc(II) chloride in diethyl ether T=0 - 20°C; Inert atmosphere; 2: benzaldehyde With (S)-N-(3-methyl-1-(1-pyrrolidin-1-yl)butan-2-yl) diphenylphosphinic amideamine in diethyl ether T=20°C; Inert atmosphere; optical yield given as percent ee;
参考文献
Chemical Communications, , vol. 46, # 30 p. 5443 - 5445
反应条件
n-butyllithium; (2S,2'S)-2-hydroxymethyl-1-lt;(1-methylpyrrolidine-2-yl)methylgt;pyrrolidine in toluene T=-110°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 37, # 23 p. 4111 - 4119
