4-氯-1-苯基磺酰基-1H-吡咯并[2,3-b]吡啶合成路线 （共 4 条）
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; p-toluenesulfonyl chloride in water; toluene T=20°C; 2.5 h;
参考文献
AVENTIS PHARMA S.A.
Patent: US2008/45561 A1, 2008 ;
Location in patent: Page/Page column 28; 24 ;
反应条件
tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide in water; toluene
参考文献
Nemecek, Conception; Metz, William A.; Wentzler, Sylvie; Ding, Fa-Xiang; Venot, Corinne; Souaille, Catherine; Dagallier, Anne; Maignan, Sebastien; Guilloteau, Jean-Pierre; Bernard, Francois; Henry, Alain; Grapinet, Sandrine; Lesuisse, Dominique
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 100 - 106
反应条件
n-butyllithium; iodine in tetrahydrofuran
参考文献
Nemecek, Conception; Metz, William A.; Wentzler, Sylvie; Ding, Fa-Xiang; Venot, Corinne; Souaille, Catherine; Dagallier, Anne; Maignan, Sebastien; Guilloteau, Jean-Pierre; Bernard, Francois; Henry, Alain; Grapinet, Sandrine; Lesuisse, Dominique
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 100 - 106
反应条件
1: With zinc in N,N-dimethyl acetamide T=20°C; 0.75 h; 2: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl acetamide T=140°C; 1.5 h;
参考文献
Aventis Pharma S.A.
Patent: US2007/93480 A1, 2007 ;
Location in patent: Page/Page column 67-68 ;
